P.062 Human coronavirus NL63 and 229E seroconversion in children

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Human coronavirus NL63 and 229E seroconversion in children.

In 2004, the novel respiratory human coronavirus NL63 (HCoV-NL63) was identified, and subsequent research revealed that the virus has spread worldwide. HCoV-229E is a close relative of HCoV-NL63, and infection with either virus can lead to the hospitalization of young children, immunocompromised persons, and the elderly. Children infected with HCoV-NL63 often develop croup, with obstruction of ...

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Human Coronavirus NL63, France

The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest ...

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Understanding Human Coronavirus HCoV-NL63

Even though coronavirus infection of humans is not normally associated with severe diseases, the identification of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly pathogenic coronaviruses can enter the human population. Shortly thereafter, in Holland in 2004, another novel human coronavirus (HCoV-NL63) was isolated from a seven-month old infa...

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Evidence of Human Coronavirus-nl63 Infection in Jordanian Children

Objective: To detect and evaluate the role of the newly recognized human coronavirus (HCoV)-NL63 and HCoV-HKU1 as aetiologic agents of acute respiratory tract infections in hospitalized Jordanian children younger than 5 years of age. Methods: Between December 2003 and May 2004, a total of 326 nasopharyngeal aspirates were collected from Jordanian children hospitalized with acute respiratory tra...

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Infectivity of human coronavirus strain 229E.

The replication of human coronavirus strain 229E was observed by using indirect immunofluorescence in infected monolayers of MRC continuous cells. By 8 h after infection, bright cytoplasmic fluorescence was detected in cells infected with human coronavirus 229E. Discrete foci of infection were observed from 8 to 16 h after infection in cells infected with high dilutions of human coronavirus 229...

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ژورنال

عنوان ژورنال: Journal of Clinical Virology

سال: 2009

ISSN: 1386-6532

DOI: 10.1016/s1386-6532(08)70125-2